This book presents an in-depth study of how the drive to optimize organizational performance can be significantly improved by investigating the causal relationships between profitability, productivity, and sustainability (PPS). This is presented through an assessment of a triple combined therapy that studies the interplay between Organizational DNA, Strategic Alignments for Value, and their implications for Sustainability. Through this approach, this volume seeks to answer critical mind-searching questions and provide useful guides as to how some firms are able to sustainably create higher value or wealth, especially through corporate entrepreneurship, or via the creation of new business models than others. In tackling the three elements of profitability, productivity, and sustainability, this book also provides greater insight through an in-depth study of the pervasively unresolved and disturbing issues surrounding the prospects of increasing the chances of success for entrepreneurial start-off ventures, making it of value to researchers, academics, and students in the fields of organizational studies, strategy, and sustainability.