Intercultural communication scholars have done important work tracing how the legacies of colonialism continue to structure our world. Missing from this corpus, however, is sustained attention to (North American) Indigeneity and its repression under settler colonialism as foundationally linked to contemporary imperialisms and Euro-American domination. Unsettling Intercultural Communication brings together essays by Indigenous and non-Indigenous authors that make a strong case for centering Indigeneity and, by extension, settler-colonialism, as core analytics that can transform the field. Drawing upon the insights of critical Indigenous studies and settler-colonial studies, the contributors approach Indigeneity not as an additive but central concept that demands thorough engagement by intercultural communication scholars if we are to make sense of the unequal and violence-ridden world that we live in. In doing so, they open some of the core intercultural concepts to deeper examination.