Exercise and diet are key factors in the etiology and prevention of chronic disease. While most books on chronic disease have a decided clinical approach, Diet, Exercise, and Chronic Disease: The Biological Basis of Prevention brings together the latest cellular- and molecular-based research on the etiology of chronic diseases and the impact of various aspects of diet and exercise on the causal mechanisms. By focusing on cellular biology, details of the integrative nature of the many different underlying factors are revealed--details that are not evident with the prevailing clinical approach to chronic disease. This book highlights chronic diseases that are major causes of mortality, and which have sufficient molecular evidence for dietary and activity-related components to their etiology. Individual chapters examine the role of diet and exercise in diabetes, atherosclerosis, osteoporosis, cancer, and neurodegenerative disease. They cover aspects such as disease etiology, effects of diet and exercise, and the cellular and molecular mechanisms of how various dietary components and repeated exercise alter disease etiology to contribute to disease prevention. Since inflammatory signaling is a fundamental component of the chronic diseases discussed, the book includes a separate chapter on inflammation and innate immune responses. Obesity as a contributing factor is addressed within the specific disease chapters. The book also reviews what is known about the factors that influence food intake in humans. This reference translates molecular-based data on etiology and prevention into a clinical prescription for the prevention of chronic disease.