In order to succeed in school, students fundamentally need to feel safe and connected--particularly when chronic stress at home, in the community, or at school makes it difficult to learn. This book explains practical ways to infuse schools with trauma-informed and culturally responsive (TICR) practices that can foster compassionate relationships, promote the well-being of students and educators alike, and unlock students' academic and social-emotional potential. Isaiah B. Pickens provides a wealth of tools for implementing TICR strategies in classroom instruction, multi-tiered systems of support, school safety planning, and professional learning. In a convenient large-size format, the book is packed with case examples, checklists, activity guides, templates for assessment, and best-practice resources. The companion website offers 41 reproducible and downloadable handouts. This book is in The Guilford Practical Intervention in the Schools Series, edited by Sandra M. Chafouleas.