This book constitutes the refereed proceedings of the 5th International Conference on Recent Trends in Image Processing and Pattern Recognition, RTIP2R 2022, held in Kingsville, TX, USA, in collaboration with the Applied AI Research Laboratory of the University of South Dakota, during December 01-02, 2022.The 31 full papers included in this book were carefully reviewed and selected from 69 submissions. They were organized in topical sections as follows: healthcare: medical imaging and informatics; computer vision and pattern recognition; internet of things and security; and signal processing and machine learning.