This two-set volume CCIS 2669 and CCIS 2670 constitutes the post-conference proceedings of the 5th International Conference on AI and Digital Transformation: Opportunities, Challenges, and Emerging Threats in Technology, Business, and Security, ICITTBT 2025 held in Tirana, Albania during May 29-30, 2025. The 65 full papers and 26 short papers presented in this volume were carefully reviewed and selected from 219 submissions. They were organized in the following topical sections: Part I: Artificial Intelligence (AI); Data Analytics and Data Science; Advancements in IoT, Networking, Cloud, Robotics, and Cybersecurity. Part II: Technology in Applied Sciences; Management, Business, Economics, and Social Sciences: Analytics, Strategy, and Governance; Digital Economy.