This book comprises peer-reviewed papers selected for presentation and discussion at the 20th Iberian Conference on Information Systems and Technologies (CISTI'2025), held from June 16 to 19, 2025, at ISEG--Lisbon School of Economics and Management, University of Lisbon, Portugal. CISTI'2025 is a leading international forum that brings together researchers, practitioners, and industry experts to exchange the latest research findings, innovative solutions, emerging trends, professional experiences, and key challenges across various domains of information systems and technologies. The conference also emphasizes recent technological advancements and their practical applications. The book covers essential topics such as: A) organizational models and information systems; B) knowledge management and decision support systems; C) software systems, architectures, applications, and tools; D) computer networks, mobility, and pervasive systems; E) human-centered computing; F) health informatics; G) information technologies in education; and H) architecture and engineering of construction. The primary audience for this publication includes postgraduate students, researchers, and academics in information systems and technologies. It also serves as an essential reference for undergraduate students and professionals in related fields.