In this ambitious two-volume open access collection of essays, a diverse group of scholars from all over the world reflects on the past, present and future of the (comparative) regionalism research program. Volume II reflects on the continued relevance of regions in current world politics, on scenarios that can be visualized in terms of their future role, and on normative arguments that claim a role for regions as important governance levels. In consecutive sections, the chapter authors explore the role of regions in global governance, the role of interregional relations, and the (regional) role and impact of regional organizations. This collection of essays celebrates and highlights the research and scholarly undertakings of the United Nations University Institute on Comparative Regional Integration Studies (UNU-CRIS) on its 25th anniversary.