This book constitutes the refereed proceedings of the 5th International Conference on Artificial Intelligence and Knowledge Processing, AIKP 2025, held in Hyderabad, India, during October 23-25, 2025. The 22 full papers included in this book were carefully reviewed and selected from 111 submissions. They explore a broad spectrum of themes including machine learning, natural language processing, computer vision, robotics, data science, quantum AI, cognitive computing, and ethical AI.