This book constitutes the proceedings of the 38th International Conference on Computer Applications in Industry and Engineering, CAINE 2025, which took place in New Orleans, LA, USA, during October 20-21, 2025. The 24 full papers included in this book were carefully reviewed and selected from 48 submissions. These papers were organized into the following topical sections: Intelligent Signals & Smart Learning Systems; Cloud Futures, Blockchain Trust & P2P Innovation; Cybersecurity Frontiers & Resilient IoT; AI Horizons - Models, Methods & Applications.