This book explores the dynamic interplay between deep tech and digital entrepreneurship. Using Brazil as the setting, it shows how scientific discoveries and emerging digital opportunities translate into innovation to address societal grand challenges within Brazil's unique context. The authors examine the challenges, opportunities, and innovative strategies of deep-tech and digital startups operating across transformative industries and ecosystems. The first part of the book focuses on the microfoundations, frameworks, and models that shape the success of deep tech ventures, including their capacity to adapt to uncertainty, build innovation readiness, and achieve commercial viability. The second part turns to digital startups and emphasizes their scalability, internationalization, and the essential role of entrepreneurial ecosystems. The book offers practical insights and actionable solutions for entrepreneurs, managers, and policymakers. The book provides a roadmap for entrepreneurs to navigate and harness the disruptive potential of deep tech and digital entrepreneurship in emerging markets and beyond by combining three major concepts: deep tech, digital, and disruptive enterprises.