This three-volume set CCIS 2854-2856 constitutes the refereed proceedings of the Third International Conference on Optimization and Data Science in Industrial Engineering, ODSIE 2025, held in Istanbul, Turkey, during November 20-22, 2025. The 94 full papers and 10 short papers included in this book were carefully reviewed and selected from 198 submissions. They are organized into the following topical sections: Part I: AI-Driven Innovations for Precision Medicine and Healthcare Optimization; Intelligent Optimization and Autonomous System Design through AI and Digital Technologies; AI and Policy-Based Cybersecurity Approaches for Urban Digital Infrastructure; Computational Intelligence and Data-Driven Strategies for Sustainable and Resilient Urban Systems; and Ethical and Legal Dimensions of Digital Governance in Modern Organizations. Part II: Computational Governance and Ethical Intelligence in Global Corporate Systems; and Intelligent Optimization and Autonomous System Design through AI and Digital Technologies. Part III: Data Analytics and AI for Cross-Sector Innovation and Global Development; and AI and Data-Driven Approaches for Sustainable Agriculture, Water Resources, and Food Systems.