This five-volume set, CCIS 2819-2823, constitutes the refereed proceedings of the 4th International Conference on Advancements in Smart Computing and Information Security, ASCIS 2025, held in Rajkot, Gujarat, India, during September 11-13, 2025. The 112 full papers and 25 short papers included in these volumes were carefully reviewed and selected from 579 submissions. They are organized into the following topical sections: Part I, II, III: Artificial Intelligence & Machine Learning Part IV: Cyber Security Part V: Smart Computing