This book offers a multidisciplinary exploration of the Mediterranean region through the lenses of environmental design, heritage conservation, urban regeneration, and sustainable territorial development. Divided into four interconnected parts, this book examines the intricate relationship between natural landscapes, architecture and archaeology, highlighting innovative approaches to environmental management and adaptive design. It focuses on heritage and identity, emphasizing the role of cultural and architectural heritage in shaping collective memory and resilience, supported by digital and analytical tools for preservation. This book addresses urban tourism and regeneration, investigating cultural and economic drivers of urban transformation, community engagement and sustainable tourism practices. Finally, the chapters of book explore landscape values and socio-economic impacts, presenting models for sustainability assessment, resilience planning and energy transition across Mediterranean contexts. Together, these contributions present a comprehensive reflection on the evolving dialogue between nature, culture and technology in shaping sustainable and equitable futures for Mediterranean territories.