This book presents the proceedings of the 4th International Conference on Advances in Information and Communication Technology (ICTA 2025) which features 58 high-quality peer-reviewed papers that demonstrate the breadth, depth, and interdisciplinary nature of contemporary ICT research. This book encompasses a wide spectrum of advanced topics, including mathematical foundations in informatics, AI-driven decision support systems for biomedical applications, bioinformatics and computational biology, electronic circuits and systems, and digital economics and management. Together, these contributions illustrate how rigorous theoretical frameworks and computational methodologies contribute to innovation in health care, engineering, and digital society. Published in the Lecture Notes in Networks and Systems (LNNS) series, this book is intended for academics, advanced students, and technology professionals, serving as a comprehensive scholarly reference and a catalyst for further research and cross-disciplinary innovation.