This volume examines the dynamics of religious and cultural interaction in medieval Sefarad and the early modern Iberian world. Leading scholars investigate coexistence, polemics, hybridity, and identity through richly documented case studies--ranging from rabbinic and Christian polemics to Converso struggles, diaspora adaptation, and literary transformation. Spanning genres and disciplines, the essays elucidate patterns of conflict and collaboration, as well as processes of conversion and continuity, among Jews, Christians, and Muslims. Bringing together fresh methodologies and rare textual insights, this interdisciplinary collection offers a fitting tribute to Moisés Orfali, whose scholarship and mentorship have shaped the field and inspired generations of students.