This book constitutes the refereed proceedings of the 22nd International Conference on Web Information Systems and Applications, WISA 2025, held in Xi'an, China, during October 1, 2025. The 47 full papers and 10 short papers presented in this book were carefully selected and reviewed from 210 submissions. These papers have been organized in the following topical sections: Information System Applications. Intelligent Computing. Intelligent Service. Knowledge Construction. Large Language Model. Security.