This 2-volume set CCIS 2778+2779 constitutes the proceedings of the Third International Conference on Applied Intelligence, ICAI 2025, held in Nanning, China, during November 6-9, 2025. The 70 full papers presented in this proceedings were carefully selected and reviewed from 289 submissions. They were organized in topical sections as follows: Part I: Image Processing; Knowledge Discovery and Data Mining; Machine Learning; Pattern Recognition. Part II: Biomedical Data Modeling and Mining; Neural Networks; Pattern Recognition.