Imagine a future where your smartphone could save your life, or an AI-enabled ultrasound device can make scanning more accurate. Healthcare organizations and experts around the world are coming together to transform how care is delivered. Authors Paul Cerrato, MA, and John D. Halamka, MD, MS, leaders in data science and healthcare strategy at the world-renowned Mayo Clinic, explore these ideas and Mayo Clinic Platform, the first comprehensive platform in healthcare that envisions a world where personalized, predictive, and innovative care is accessible to all. Today's digital tools include apps that detect abnormal heart rhythms, skin cancer, and other life-threatening conditions. They can identify early onset diabetes and improve the detection rate of colorectal cancer. High-quality, at-home cancer care is becoming a reality. Welcome to the new era of digital health, where advanced technology and big data revolutionize the way you and your loved ones receive care. Mayo Clinic Platform is the first AI-enabled comprehensive healthcare platform aimed at making top-tier healthcare available to everyone--no matter where they are--through cutting-edge data science, analytics, and innovative business applications. This ambitious project, targeted at solving some of the most pressing healthcare issues, includes healthcare service providers, pharmaceutical companies, medical device firms, health tech startups, and patients located on four continents. Touching approximately 56 million patient lives in 2024, the Platform's groundbreaking efforts are already making a global impact. Using Platform architecture, Mayo Clinic and its partners are revolutionizing the practice of medicine, resulting in faster, more accurate and more efficient diagnosis, improved treatment approaches, and quicker delivery of new cures to patients, with more exciting developments on the horizon. Welcome to the journey.